During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality. Based on the award-winning light novels of the same name, Baccano! follows several events that initially seem unrelated, both in time and place, but are part of a much bigger story—one of alchemy, survival, and immortality. Merging these events together are the kindhearted would-be thieves, Isaac and Miria, connecting various people, all of them with their own hidden ambitions and agendas, and creating lifelong bonds and consequences for everyone involved. [Written by MAL Rewrite]

The Amanto, aliens from outer space, have invaded Earth and taken over feudal Japan. As a result, a prohibition on swords has been established, and the samurai of Japan are treated with disregard as a consequence. However one man, Gintoki Sakata, still possesses the heart of the samurai, although from his love of sweets and work as a yorozuya, one might not expect it. Accompanying him in his jack-of-all-trades line of work are Shinpachi Shimura, a boy with glasses and a strong heart, Kagura with her umbrella and seemingly bottomless stomach, as well as Sadaharu, their oversized pet dog. Of course, these odd jobs are not always simple, as they frequently have run-ins with the police, ragtag rebels, and assassins, oftentimes leading to humorous but unfortunate consequences. Who said life as an errand boy was easy? [Written by MAL Rewrite]

To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this couldn't be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss. Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected. [Written by MAL Rewrite]

For weeks, Atsushi Nakajima's orphanage has been plagued by a mystical tiger that only he seems to be aware of. Suspected to be behind the strange incidents, the 18-year-old is abruptly kicked out of the orphanage and left hungry, homeless, and wandering through the city. While starving on a riverbank, Atsushi saves a rather eccentric man named Osamu Dazai from drowning. Whimsical suicide enthusiast and supernatural detective, Dazai has been investigating the same tiger that has been terrorizing the boy. Together with Dazai's partner Doppo Kunikida, they solve the mystery, but its resolution leaves Atsushi in a tight spot. As various odd events take place, Atsushi is coerced into joining their firm of supernatural investigators, taking on unusual cases the police cannot handle, alongside his numerous enigmatic co-workers. [Written by MAL Rewrite]