In the year 2029, Niihama City has become a technologically advanced metropolis. Due to great improvements in cybernetics, its citizens are able to replace their limbs with robotic parts. The world is now more interconnected than ever before, and the city's Public Security Section 9 is responsible for combating corruption, terrorism, and other dangerous threats following this shift towards globalization. The strong-willed Major Motoko Kusanagi of Section 9 spearheads a case involving a mysterious hacker known only as the "Puppet Master," who leaves a trail of victims stripped of their memories. Like many in this futuristic world, the Puppet Master's body is almost entirely robotic, giving them incredible power. As Motoko and her subordinates follow the enigmatic criminal's trail, other parties—including Section 6—start to get involved, forcing her to confront the extremely complicated nature of the case. Pondering about various philosophical questions, such as her own life's meaning, Motoko soon realizes that the one who will provide these answers is none other than the Puppet Master themself. [Written by MAL Rewrite]

All of a sudden, they arrived: parasitic aliens that descended upon Earth and quickly infiltrated humanity by burrowing into the brains of vulnerable targets. These insatiable beings acquire full control of their host and are able to morph into a variety of forms in order to feed on unsuspecting prey. Sixteen-year-old high school student Shinichi Izumi falls victim to one of these parasites, but it fails to take over his brain, ending up in his right hand instead. Unable to relocate, the parasite, now named Migi, has no choice but to rely on Shinichi in order to stay alive. Thus, the pair is forced into an uneasy coexistence and must defend themselves from hostile parasites that hope to eradicate this new threat to their species. [Written by MAL Rewrite]

Within the domed city of Romdo lies one of the last human civilizations on Earth. Thousands of years ago, a global ecological catastrophe doomed the planet; now, life outside these domes is virtually impossible. To expedite mankind's recovery, "AutoReivs," humanoid-like robots, have been created to assist people in their day-to-day lives. However, AutoReivs have begun contracting an enigmatic disease called the "Cogito Virus" which grants them self-awareness. Re-l Mayer, granddaughter of Romdo's ruler, is assigned to investigate this phenomenon alongside her AutoReiv partner Iggy. But what begins as a routine investigation quickly spirals into a conspiracy as Re-l is confronted by humanity's darkest sins. Elsewhere in Romdo, an AutoReiv specialist by the name of Vincent Law must also face his demons when surreal events begin occurring around him. Re-l, Iggy, Vincent, and the child AutoReiv named Pino, will form an unlikely faction as they struggle to uncover Romdo's mysteries and ultimately, discover the true purpose of the mythical beings called "Proxies." [Written by MAL Rewrite]

Lain Iwakura, an awkward and introverted fourteen-year-old, is one of the many girls from her school to receive a disturbing email from her classmate Chisa Yomoda—the very same Chisa who recently committed suicide. Lain has neither the desire nor the experience to handle even basic technology; yet, when the technophobe opens the email, it leads her straight into the Wired, a virtual world of communication networks similar to what we know as the internet. Lain's life is turned upside down as she begins to encounter cryptic mysteries one after another. Strange men called the Men in Black begin to appear wherever she goes, asking her questions and somehow knowing more about her than even she herself knows. With the boundaries between reality and cyberspace rapidly blurring, Lain is plunged into more surreal and bizarre events where identity, consciousness, and perception are concepts that take on new meanings. Written by Chiaki J. Konaka, whose other works include Texhnolyze, Serial Experiments Lain is a psychological avant-garde mystery series that follows Lain as she makes crucial choices that will affect both the real world and the Wired. In closing one world and opening another, only Lain will realize the significance of their presence. [Written by MAL Rewrite]