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An ocean city, Tristia. Tristia used to be prospering playing an important role of the maritime trade, and it was as beautiful as to be praised as "marine jewelry". However, that was a long time ago. The attack of the dragons deprived the city of their original brightness. The people in Tristia worked hard to reconstruct their city, but everything they did went wrong, and the city became desolated on the contrary. At the end of their hope, they asked a Great Artisan for the recovery of the city, Prospero Flanka. Prospero was a legendary inventor who had revived cities that otherwise would have been ruined. The long-awaited day came when the Great Artisan Prosper arrived in the city... However, it was only one girl who stood at the port of the city. Prospero sent his grand daughter, Nanoka, for him. (Source: AnimeNfo)

The genius robotics professor, Dr. Komyoji has created Jiro (who has the ability to transform into Kikaider) – a humanoid robot tasked with the protection of Dr. Komyoji’s son, Masaru, and daughter, Mitsuko. Gifted with a conscience circuit, which has the power to simulate real emotions that helps to distinguish between “right and wrong”, Jiro must protect Mitsuko and Masaru from the evil Dr. Gil who wants Jiro to join his army and aid in his goal of world domination. (Source: ANN)

Nanako is a an inept apprentice nurse to the brilliant young Dr. Kouji. Now for some reason, Nanako is always being targeted by various elements which makes Nanako wonder if she has done anything wrong. But there are certain secrets to Nanako's past that only Dr. Kouji and his family know about.

Each episode centers on Nuku Nuku's adventures and mishaps in high school, and her relationship to students, the overall series plot centers on the evil Mishima Industries' scheme to dominate the world through its products. In opposition to this plan are the slightly nutty Kyuusaku Natsume and Nuku Nuku, the android who acts as a companion to his young son. Nuku Nuku's classmates are all eccentrics, Futaba, the class president, is a domineering control-freak, who cannot leave her authority in school. Chieko Shirakaba is the rich snob with the two yes-girls who always take her side. There is a bookworm, a mystic, a scientist, and a pop singer. All of these are true to their descriptions: the mystic is always foretelling doom via tarot cards, spirits, or some other occult technique. The pop singer never says anything except as a song. The bookworm always has her nose in a book. These eccentricities add to the series' humor. (Source: ANN)